Pearl Jam are the latest music act to cancel a concert in North Carolina over the US state's controversial transgender public toilet law.
The US rockers said the new law, known as HB2, was "a despicable piece of legislation that encourages discrimination against an entire group of American citizens", as they joined Bruce Springsteen, Ringo Starr and Boston in pulling out of a gig in the state.
It follows governor Pat McCrory's decision to sign off on legislation dictating that people must use toilets and changing rooms based on the gender recorded on their birth certificate, which campaigners say discriminates against trans people.
In a statement on their website, Pearl Jam said: "It is with deep consideration and much regret that we must cancel the Raleigh show in North Carolina on April 20th.
"This will be upsetting to those who have tickets and you can be assured that we are equally frustrated by the situation.
"The HB2 law that was recently passed is a despicable piece of legislation that encourages discrimination against an entire group of American citizens.
"The practical implications are expansive and its negative impact upon basic human rights is profound. We want America to be a place where no one can be turned away from a business because of who they love or fired from their job for who they are.
"It is for this reason that we must take a stand against prejudice, along with other artists and businesses, and join those in North Carolina who are working to oppose HB2 and repair what is currently unacceptable."
Mr McCrory signed the law that limits protection for lesbian, gay, bisexual and transsexual (LGBT) people but has since backtracked amid a backlash from politicians, musicians and major companies including Deutsche Bank.
He has extended certain protections but stopped short of repealing the legislation and the rules on public toilets remain in schools and government buildings.
Bryan Adams also cancelled a gig in Mississippi over the state's laws allowing religious groups and businesses to refuse to serve gay people.