The Simpsons will be airing an hour-long episode in January.
It will be the first time the half-hour animated series has expanded to a full hour, Fox said.
Al Jean, executive producer of the series, included a political shot in announcing the episode.
"I just pray it won't be the last thing people see before a Trump inauguration," Al said in a statement.
Taraji P Henson, who plays Cookie on Fox's Empire and Keegan-Michael Key will guest star.
Taraji voices Praline, the former wife of a music mogul who has conned Mr Burns into bankruptcy.
Keegan-Michael voices a rapper, Jazzy James, who joins with Praline, Homer and Bart to help Mr Burns seek revenge.
The airdate for the episode, titled The Great Phatsby, a play on the classic The Great Gatsby, has not yet been announced.
The Simpsons begins its 28th season on September 25 and will reach its 600-episode milestone October 16.