Professor Stephen Hawking will be honoured with a concert that features Queen's Brian May and Hans Zimmer.
Retired astronaut Chris Hadfield, who famously recorded Space Oddity on board the International Space Station, will perform the song live for the first time in a special tribute to David Bowie and Hawking.
The Canadian will swap outer space for the terrestrial destination of Tenerife as he joins Rick Wakeman to reinterpret Bowie's hits at the third Starmus Festival.
Soprano Sarah Brightman, who postponed her trip to become the first professional singer in space last year, will also be giving an out-of-this-world performance for Hawking.
The science and music festival brings the performers together with 11 Nobel Prize laureates and famous scientists including Neil deGrasse Tyson, Brian Cox and Richard Dawkins.
Keynote speaker Brian Eno will throw a Star Party as well as talk on the topic "At the Crossroads of Art and Science".
Zimmer is among the winners of the inaugural Stephen Hawking Medal for Science Communication for his work on the film Interstellar.
The German composer, whose scores include Gladiator, The Lion King and The Dark Knight trilogy, was personally selected by Hawking for his outstanding contribution to the portrayal of science to the public for his work on the Matthew McConaughey film.
Hawking will hand him the first medal of arts "for the music to Interstellar, a science-fiction film with credible physics" at a ceremony on June 29.
The documentary film Particle Fever, about physicists at the Large Hadron Collider at Cern, culminating in their discovery of the Higgs boson particle, wins the film award.
Physicist and broadcaster Jim Al-Khalili will accept the science medal "for his treatment of complex physics concepts through science documentaries, most recently, The Secrets Of Quantum Physics".
Starmus Festival will run from June 27 to July 2 on the Canary Islands of Tenerife and La Palma.